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Document 2534
DOCN M94A2534
TI HIV-1 and HIV-2 status in Ghanaian AIDS and ARC patients.
DT 9412
AU Ayisi KN; Ishikawa K; Magnusen AF; Sata T; Mensah M; Noguchi Memorial
Inst. for Med. Res. Ghana.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):282 (abstract no. PC0049). Unique
Identifier : AIDSLINE ICA10/94370041
AB We have used the particle agglutination (PA) test, Western blot (WB)
test, polymerase chain reaction (PCR) test and virus isolation to define
human immunodeficiency virus (HIV) status of 17 acquired immune
deficiency syndrome (AIDS), 6 AIDS related complex (ARC), and 2
asymptomatic Ghanaians. HIV-1 antibodies were more frequently detected.
PCR detected HIV-1 and HIV-2 proviral DNA in 81.2% (13/16) and 18.8%
(3/16) respectively of HIV positive samples. Of the 12 viruses isolated,
9 were HIV-1, 2 were HIV-2 and both HIV-1 and HIV-2 were isolated from
one individual. Two of the HIV-1 isolates were from ARC patients who
have been either HIV-1 or HIV-2 indeterminate for more than one year
without becoming seropositive. Our results indicate that HIV-1 is now
predominant in Ghanaian AIDS and ARC patients and that the
serodiagnostic window for HIV detection in Ghana may extend beyond one
year or that antigens in commercially available kits may not detect
antibodies to certain strains of HIV in Ghana.
DE Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Agglutination Tests
AIDS-Related Complex/*MICROBIOLOGY Blotting, Western Ghana Human
HIV-1/*ISOLATION & PURIF HIV-2/*ISOLATION & PURIF Polymerase Chain
Reaction MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).